Synergistic Skin Science: A Deep Dive into Regeneration and Hydration

Jean Pierre Ribeiro Daquila, PhD Biomedicine, UNICID Brazil

🔬 Synergistic Skin Science: A Deep Dive into Regeneration and Hydration

Modern skincare is advancing well beyond simple moisturization, now focusing on advanced ingredients that leverage cellular communication and deep repair. A potent combination for comprehensive skin rejuvenation includes Polydeoxyribonucleotides (PDRN), Pro-Vitamin B5 (Panthenol), Hyaluronic Acid (HA), and Cica-derived Exosomes. Scientific literature explores how these distinct mechanisms work together to fortify the skin barrier, boost regeneration, and significantly enhance hydration.

PDRN: The Nucleotide for Tissue Repair

Polydeoxyribonucleotides (PDRN) are highly purified DNA fragments, often sourced from salmon, and are gaining significant traction in regenerative medicine due to their ability to promote tissue repair and temper inflammation ​(Colangelo et al., 2020).

. The core benefits of PDRN center around

sophisticated cellular signaling: it primarily works by activating adenosine A_{2A} receptors, and this binding stimulates cell growth by promoting the proliferation of both keratinocytes and fibroblasts. Furthermore, clinical studies show PDRN enhances wound closure, accelerates re-epithelialization, and promotes angiogenesis (new blood vessel formation), making it highly effective for various skin challenges, including ulcers and compromised barriers. Ultimately, by stimulating collagen synthesis and supporting soft tissue regeneration, PDRN is considered a powerful anti-aging agent, improving skin elasticity and overall health.

Pro-Vitamin B5 (Panthenol): Barrier and Soothing Support

Pro-Vitamin B5, commonly known as Panthenol, is an alcoholic analog of the water-soluble vitamin B5 (pantothenic acid) and is a time-tested ingredient for maintaining skin integrity. Once applied topically, Panthenol converts into pantothenic acid, which is essential for healthy epithelial function. It acts

as both a humectant (binding water effectively) and an emollient (sealing tiny cracks in the skin). This crucial dual action significantly reduces Transepidermal Water Loss (TEWL), thereby strengthening the epidermal barrier. Additionally, research suggests Panthenol offers potent moisturizing and anti-inflammatory actions, helping to mitigate irritation and soothe compromised conditions like atopic dermatitis (Kokande et al., 2024). Moreover, Panthenol is linked to the stimulation of fibroblast proliferation and accelerated epithelialization, which is vital for the healing of superficial wounds.

Hyaluronic Acid: Master of Hydration and Structure

Hyaluronic Acid (HA), a glycosaminoglycan, is a critical component of the skin's extracellular matrix (ECM), and its role is fundamentally tied to water retention and structural organization. Its unique capacity to bind and retain vast amounts of water (up to 1,000 times its weight) makes HA the key molecule for skin moisture (Bravo et al., 2022). This resulting viscoelastic

network provides long-lasting hydration, dramatically reducing dryness and roughness. Consequently, by maintaining optimal hydration, HA is essential for the skin's elasticity and firmness. Injectable and topical applications have been shown to improve skin appearance, hydration, and reduce the visibility of fine lines and wrinkles. Interestingly, the efficacy of HA often depends on its molecular weight (MW): High-MW HA focuses on surface hydration and structural stability, while low-MW HA is associated with deeper penetration, stimulation of cell migration, and support for early regenerative responses.

Cica Exosomes: Targeted Delivery and Calming

Centella asiatica (Cica)-derived Exosomes represent a cutting-edge approach utilizing extracellular vesicles (EVs) to deliver bioactive signals directly to skin cells. Cica itself is well-known for its healing and soothing effects due to its phytochemical content (like triterpenoids). These exosomes function as microscopic messengers, transferring vital proteins and genetic material between cells to facilitate

complex processes, and Cica EVs are noted for promoting skin improvement more effectively than basic plant extracts alone (Park & Shin, 2025). Because of this, research indicates that Cica-derived exosomes possess powerful regenerative and anti-inflammatory properties. This synergy accelerates skin recovery and enhances calming for stressed or irritated skin. Clinical evaluations of Cica EVs demonstrate multifaceted benefits, showing improvements in dermal density, reduction in wrinkle depth, and enhanced hydration, marking them as innovative agents for anti-aging and skin repair.

🔑 Conclusion: Unlocking Comprehensive Skin Renewal

The combined power of these four components—PDRN’s regenerative signaling, Panthenol’s barrier reinforcement, HA’s moisture retention, and Cica Exosomes’ targeted repair and calming—offers a truly comprehensive strategy for tackling skin aging, damage, and dehydration. This multi-pathway approach successfully targets the skin's structure, hydration levels, and cellular renewal processes simultaneously,

ultimately fostering a healthier, more resilient dermal and epidermal state. A formulation that strategically integrates these scientifically-backed elements, such as J'Exo-PDRN, provides a highly synergistic medium. By combining the strengths of nucleotide-based regeneration, targeted extracellular vesicles, profound hydration, and epidermal repair factors, this type of product is optimally positioned as an effective solution for delivery methods like microneedling, maximizing the clinical benefits of cellular and tissue renewal.

References: 

Bravo B, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D. (2022). Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatologic Therapy. 35(12):e15903. doi:10.1111/dth.15903

​Colangelo, M. T., Galli, C., & Guizzardi, S. (2020). The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a

systematic review of the literature. Regenerative Medicine, 15(6), 1801–1821.

Kokande, A. M., Surana, K. R., Ahire, E. D., Keservani, R. K., & Mahajan, S. K. (2024). Vitamins as nutraceuticals for skin care. In Preventive and therapeutic role of vitamins as nutraceuticals (1st ed., p. 18). Apple Academic Press.

Park, H. S., & Shin, S. (2025). Clinical Efficacy and Safety Evaluation of a Centella asiatica (CICA)-Derived Extracellular Vesicle Formulation for Anti-Aging Skincare. Cosmetics, 12(4), 135. https://doi.org/10.3390/cosmetics12040135